The growing frame of Arsenic is a significant public health concern now a day. Although arsenic is a well known carcinogen which leads to the induction of different types of cancers, it also been recently recommended as one of the most effectual novel anticancer agent for the treatment of various types of cancer including acute promyelocytic leukaemia (APL). However the exact metabolic mechanism induces due to arsenic and its compounds are still a question to be answer. The revival of this metalloid in treating APL is a unique story in cancer therapy. Based on these facts, Here we focused the effect of arsenic trioxide alone or its combination with other existing supplements in different types of cancer, and these strategies may enlightening in near future with respect to precious uses of arsenicals as medicines for treating cancer. Along with this it also requires to understand how arsenic emphasizes its toxic effects and how its implication leads to novel therapeutic advances. Hence there is an urgent need for better understanding of paradoxical effect of arsenic which may have a potential to become an appropriate treatment of various types of malignancies. Making concern in the area, in this review we focused its targeted pathways which would be helpful in shedding light on its actual role in relation to toxicity as well as in potential drug.
Archana Chaudhary and Rizwanul Haque*