Coronary artery disease is considered as major cause of death all over the world. Although it is associated with traditional risk factors like age, gender, hypertension, diabetes, smoking, such phenotypes also have strong association with genetic background. Here we reviewed the available data concerned to CAD traditional as well as genetic markers along with contributing genes and their interactions with environment. CAD as a polygenic disease possess about 50%-60% heritability causing difficulty in understanding its genetic architecture. Besides, complicated pathophysiological processes including both genetic and environmental interactions may increase or decrease the CAD risk depending upon the expression of concerned genes. In future, adequate genetic markers may be identified presenting risk profile to prevent CAD.
Najma Qammar*, Maryam Zain and Hafiz Muhammad Rashad Javeed