Effects of insulin on ADPN and AdipoR1 in diabetic rats

ADEL MOHAMED GOURI

Abstract

Effects of insulin on ADPN and AdipoR1 in diabetic rats

In this study, we have investigated insulin resistance (IR), plasma adiponection (ADPN) and ADPN receptors (AdipoR) expression in high-fat (HF) diet fed (8 weeks) rats with or without streptozotocin (STZ) treatment (30 mg/kg i.p.). Our results show that HF diet either alone or in combination with STZ treatment decreased plasma levels of ADPN and expression of muscle AdipoR. These disorders were improved with insu- lin (INS) treatment (1 IU/kg i.p.). In conclusion, our results suggest that ADPN might play an important role in amelioration of IR in these experimental model of type 2 diabetes.