We report a case of a 60-year-old woman, which presented severe burns from a gas cylinder explosion in domestic accident. The burned body surface was about 35% with second and third degree burns. To ensure intravenous fluid resuscitation, a central femoral venous catheterization was decided, but during the procedure, the guidewire was pushed into the femoral vein by physician. The pelvic x-ray showed the guidewire in the femoral vein. It was successfully surgically extracted from right common iliac vein. This complication is rare and avoidable. Factors that contribute to a guidewire loss into circulation include operator inexperience, lack of supervision and inattention. The prevention is the best treatment and simulation training can significantly help to reduce this complication.