Gokhale SG*, Kadrekar Meena and Gokhale Sankalp
Department of Pediatrics and Neonatology, Rajhans Hospital and Research Center, Saphale, India
Received date: August 02, 2017; Accepted date: August 10, 2017;; Published date: August 14, 2017
Citation: Gokhale SG, Meena K, Sankalp G. Estimation of Vitamin D levels in women of child bearing age group from countryside: A retrospective observational analytical study. Arch Med. 2017, 9:4. doi: 10.21767/1989-5216.1000235
In spite of abundant sunlight Vitamin-D deficiency is quite common in Middle East, Asian countries and India [1-3]. Many Indian studies are available recruiting mainly urban population. We went to determine status of Vitamin-D deficiency in local population. Here people are engaged in agricultural activities, no industrial pollution either. This is probably first study focusing on country side population.
We collected data about Vitamin-D levels in women of child bearing group from record section starting November 01, 2014 to December 31, 2016. Blood samples for Vitamin-D/ Hemoglobin estimations were collected by peripheral venepuncture. Hemoglobin was estimated by standard Drabkin’s Reagent Method. Vitamin- D levels were estimated by LCMSMSLiquid Chromatography Tandem Mass Spectrometry . This technique and machine measures serum vitamin-D levels beyond 4.2 monograms/ml. So values less than 4.2 nanograms/ml are read as UNDETECTABLE.
There were 451 participants; their age ranging from 18 years to 49 years (Figure 1).
Only 14 Women had Vitamin-D levels more than 30 ng/ml [9/451=3.01%]. Only 46 women [46/451=10.2%] were holding office/indoor jobs; 405/451 worked [89.8%] in open fields/ busy in agricultural activities. 26 women [5.8%] had very low or Undetectable Vitamin-D levels, 265 [58.7%] had Vitamin-D levels more than 4.2 but less than 15 and 146 participants [32.3%] had Vitamin-D levels more than 15, but less than 30 nanograms/ml. Only 14 women [3.2%] had vitamin- d levels more than 30. 12 were unmarried and did not have children. One was married but non-pregnant 280/451 participants were first para, 155 had two babies, two had five children, and one was grand multipara [8 babies]. 37/451=8.12% had reasonable hemoglobin levels at or more than 12 gms/dl. Only 3.01% showed vitamin-D more than 30 ng/ml, or in other words 96.89% moms were vitamin-D deficient.
The problem of vitamin-D deficiency with abundant sunshine is multifaceted. Serum levels of Vitamin-D more than 30 ng/ml (to convert ng/ml to nmol/ml multiply by 2.5) are considered as ‘normal’. Levels between 20 and 30 ng/ml are defined as ‘insufficiency’ and levels less than 20 ng/ml are defined as ‘deficiency’ . Genetic factors like-Genetic variability of Vitamin-D Binding Protein and ‘HIGH 24-25 HYDROXYLASE ENZYME ACTIVITY’ seem to be operating [6-8]. Additionally women wear cultural dresses like Saree, Ghunghat or Burqa covering entire body with NO exposure to sunlight (Figure 2).
Many people are not aware of benefits of Vitamin-D and sunlight.
Could this be an adaptation, or an evolutionary change to prevent excessive levels of vitamin-D? Irrespective of etiology, the magnitude of the problem is significant and deserves implementation of preventive measures.
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