Ambiguity of Propranolol Side Effects in 100 Patients Treated for Infantile Hemangioma

Background: Infantile hemangiomas are the most common tumor of infancy. Propranolol hydrochloride has been prescribed for decades in the pediatric population for a variety of disorders. Since 2008 propranolol has replaced corticosteroids to become the first line of treatment for infantile hemangioma due to its high effectiveness and low rate of side effects. Of the side effects reported, the most serious yet rare side effects include: hypoglycemia, bronchial hyper-responsiveness, hypotension and bradycardia.
Objective: To describe the effects and side effects of propranolol treatment among 100 pediatric patients.
Conclusion: Propranolol has a long history of safe and effective use in infants and children, and was well tolerated in our study. Understanding and recognition of deleterious adverse effects is critical for physicians and caregivers. Outpatient treatment is possible if parents follow strict guidelines. Educating parents about mild and transient symptoms could prevent unnecessary concern.


Danielle H, Dor L, Avraham L

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