Procedures performed in the past with N ≥ 19
Step 1 Calculate median estimated blood loss (EBL)
(Absent data regarded as not being larger than median)
Step 2 Select minimal EBL threshold
Smallest median EBL where the lower 95% confidence limit for erythrocyte transfusion was >5%
Formula: 1-BETAINV(1-0,05,n-m+1,m)
Step 3 If median EBL→threshold à calculate 95% confidence limit for m.
Conclusion If value step 3→5% à no TS indicated
EBL= estimated blood loss, N= sample size, m= transfusion incidence
Table 1: Regime proposed by Dexter et al. [1].