Received date: January 23, 2017; Accepted date: February 23, 2017; Published date: February 28, 2017
Citation: Gill D, Mann K, Kaur S, Ruiz VG, Dean R, et al. Sjogren’s Syndrome in a Patient with Maculopapular Cutaneous Mastocytosis. Arch Med.2017, 9:1
Copyright: © 2017 Gill D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Methicillin-resistant Staphylococcus aureus (MRSA) is typically considered a nosocomial pathogen, however it has now emerged to cause infections in the community. We report a case of MRSA bacteremia with subdural empyema and occipital osteomyelitis in a female with a history of significant intravenous drug use (IVDU). There are very few reports on MRSA bacteremia leading to problems with central nervous system (CNS) involvement.
Staphylococcus aureus; Vancomycin; Linezolid
A 27-year-old female with past medical history significant for IVDU presented to emergency department with neck pain, and occipital headache for 1 week. She admitted to recent heroin use. Her vitals were significant for, blood pressure of 102/67 mm Hg, pulse of 116 beats per minute, temperature 36.9°C (oral), respiratory rate of 19 breaths per minute, oxygen saturation of 96% on room air. Physical exam was remarkable for left shoulder hematoma and track marks bilaterally on arms. WBC count was with normal range. Blood cultures grew MRSA, susceptible to vancomycin. Transesophageal echocardiogram showed 6.9 mm tricuspid valve vegetation. MRI brain showed left subdural empyema (Figure 1) and associated osteomyelitis within the overlying occipital bone (Figure 2). MRI head showed left transverse sinus thrombosis extending superiorly into an occipital lobe cortical vein with evidence of collateralization of flow within the overlying occipital bone (Figure 3). Neurosurgery did not recommend any surgical intervention. Follow up head MRI showed decrease in the size of the subdural empyema. Patient completed 6-week course of vancomycin and her symptoms improved.
The patient in our case report developed bacteremia from MRSA due to significant IVDU and it had disseminated into the central nervous system. Treating CNS disease due to MRSA is challenging because of few therapeutic options, and difficulty in attaining therapeutic concentration of the drug in cerebrospinal fluid (CSF). Vancomycin is the main treatment, however in some patients vancomycin therapy fails because of its poor CSF penetration . There are some cases where linezolid has been successful, due to its greater CSF penetration [2,3]. Even though there are many CNS disease occurring from MRSA, it is rare to find CNS disease development from community acquired MRSA. Hence, clinicians should have a high index of suspicion for subdural empyema in IVDUs who present with headaches and neck pain. Recognition and treatment of subdural empyema as a complication of bacteremia in IVDU is very important due to its complication rate. As evident in this case, thrombosis of the venous sinus can lead to venous occlusion and sometimes even brain infarction. Surgical and/or medical treatment should not be delayed.
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